Our research explores brain temperature as an active regulator of neuroplasticity. We investigate how physiological and pharmacological changes in brain temperature shape TrkB/BDNF signaling, synaptic plasticity, and network function, with direct relevance to sleep, stress, anesthesia, and rapid-acting antidepressant mechanisms.
Brain temperature is not merely a passive reflection of metabolism—it is a dynamic physiological variable that actively shapes neuronal signaling, synaptic plasticity, and brain function
Synaptic plasticity—the ability of synapses to strengthen or weaken over time—is the fundamental mechanism by which the brain adapts to experience
Depression is increasingly understood as a disorder of maladaptive neural plasticity rather than a simple imbalance of neurotransmitters
We combine in vivo and in vitro approaches with cutting-edge molecular and computational techniques. We also enjoy building custom research equipment and developing new experimental pipelines.
Jane and Aatos Erkko Foundation, Finnish Cultural Foundation, Sigrid Jusélius Foundation, Instrumentarium Science Foundation, University of Helsinki – Doctoral School Brain & Mind
Bettina Soinila
We are always looking for motivated students and researchers to join our team. If you are interested in a BSc or MSc thesis project, a PhD position, or postdoctoral research in our group, we encourage you to get in touch.
Kohtala lab group photo 04/2026