Our research explores brain temperature as an active regulator of neuroplasticity. We investigate how physiological and pharmacological changes in brain temperature shape TrkB/BDNF signaling, synaptic plasticity, and network function, with direct relevance to sleep, stress, anesthesia, and rapid-acting antidepressant mechanisms.
Recent publicationsBrain temperature is not merely a passive reflection of metabolism—it is a dynamic physiological variable that actively shapes neuronal signaling, synaptic plasticity, and brain function
Synaptic plasticity—the ability of synapses to strengthen or weaken over time—is the fundamental mechanism by which the brain adapts to experience
Depression is increasingly understood as a disorder of maladaptive neural plasticity rather than a simple imbalance of neurotransmitters
We combine in vivo and in vitro approaches with cutting-edge molecular and computational techniques. We also enjoy building custom research equipment and developing new experimental pipelines.
Jane and Aatos Erkko Foundation, Finnish Cultural Foundation, Sigrid Jusélius Foundation, Instrumentarium Science Foundation, University of Helsinki – Doctoral School Brain & Mind, Tor, Joe and Pentti Borg Foundation
Principal Investigator
Samuel graduated as a Master of Science in Pharmacy from the University of Helsinki in 2015, focusing on neuropharmacology. He received his PhD (pharm.) from the University of Helsinki in 2019, with distinction, after completing his doctoral work in the Laboratory of Neurotherapeutics led by Dr. Tomi Rantamäki. His PhD research focused on the shared neurobiological mechanisms of antidepressant and anesthetic drugs. Following his doctoral studies, he received the Albert Wuokko Young Researcher Award.
He completed an important part of his postdoctoral training at Weill Cornell Medicine in New York from 2020 to 2022 as a Sigrid Jusélius Visiting Fellow of Neuroscience in Psychiatry, working under the mentorship of Dr. Conor Liston and Dr. Francis S. Lee, internationally recognized experts in systems neuroscience, psychiatry, and neurotrophic signaling. Samuel was awarded the Title of Docent in Neuropharmacology in 2025.
In November 2025, Samuel established his independent research group at the University of Helsinki with the support of Jane and Aatos Erkko Foundation, Finnish Cultural Foundation, and Sigrid Jusélius Foundation. His current research investigates how brain temperature and other physiological state variables regulate neuroplasticity, neurotrophic signaling, and the effects of psychoactive and antidepressant drugs.
Outside the laboratory, Samuel enjoys building art installations, exploring the interface between science and art, practicing historical European martial arts, and working on hands-on projects at his summer cottage.
Bettina Soinila
Milestones, events, and moments from the laboratory.
A neuroscience art installation by Samuel Kohtala, Iina Annala, and Soma Szentkirályi-Tóth is now on display as part of the Purkutaide 2026 exhibition. The installation explores the visual and experiential dimensions of neuroscience research. Visit neurons.fi for more information about the work.
We are open to hearing from motivated students and researchers interested in joining the Kohtala Lab. We welcome enquiries from prospective BSc and MSc thesis students, PhD applicants, and postdoctoral researchers whose interests align with our research goals.
At present, we do not have open salaried positions. MSc thesis projects are typically not salaried positions. PhD and postdoctoral applicants are strongly encouraged to explore external funding opportunities, and applicants with their own funding or a concrete funding plan are especially welcome to get in touch. Exceptional applicants may also be considered should suitable future project funding opportunities arise.
Prospective applicants should send a free-form application including:
Applications should clearly indicate whether the enquiry concerns a BSc thesis, MSc thesis, PhD project, postdoctoral position, or another form of research visit or collaboration.
Please note that we receive a large number of enquiries. To help us assess potential fit, applications should be specific about the applicant's research interests, relevant experience, and why they are interested in our lab. We may not be able to respond individually to all enquiries, but applications will be reviewed when suitable supervision, project, or funding opportunities arise.
Kohtala lab group photo 04/2026